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20/04/2016
Cellular immortality is a near-universal phenotype of cancer cells with the central role played by the multicomponent telomerase complex firmly...
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07/11/2015
Glutamine is an essential nutrient for cancer cells and is used to support cancer cell growth. Glutamine is converted to glutamate by the enzyme...
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07/11/2015
MTH1 is a protein that sanitizes oxidized dNTPs in the cell. It preferentially hydrolyzes 8-oxo-dGTP and 2-OH-dATP to their corresponding...
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03/11/2015
The development of targeted therapies is a critical cornerstone in the fight against Cancer. A key part of this process is the development of...
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02/11/2015
Autotaxin (ATX) is an extracellular lyso-phospholipase that cleaves choline from lysophosphatidylcholine to produce lysophosphatidic acid (LPA)....
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21/09/2015
The GLS1 (glutaminase) project is part of an alliance between AstraZeneca and Cancer Research Technology to develop drugs targeting cancer...
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02/09/2015
The interest in dissecting the relevance of different jumonji domain (JMJ)-containing KDMs as therapeutic targets in cancer and human disease is...
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02/09/2015
Pan-assay Interference Compounds (PAINS) are often, if not always, present in screening libraries. The activity of these compounds is not...
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02/09/2015
The validation of hits resulting from a high throughput screening campaign is a critical part of the development of small molecule drugs. After...
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02/09/2015
The Northern Institute for Cancer Research (NICR) and CRT have recently collaborated on a screening campaign in order to initiate a drug discovery...
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