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Lead Optimisation

Our medicinal chemists combine the iterative methods of rational drug design, bringing in computational chemistry and structural biology, with cutting edge knowledge of synthetic organic chemistry. Over two thirds of our chemists have been recruited from biopharmaceutical companies, and with the experience and insight they bring we have built a professional, efficient and productive group. Physicochemical and ADME properties are central to our design principles to ensure that we focus on synthesising drug-like compounds. The medicinal chemistry team also supports target evaluation and assay development efforts through the identification and sourcing or synthesis of tool compounds. Our internal DMPK capabilities encompass the measurement of in vitro ADME properties as well as the bioanalysis of novel compounds and their metabolites in varying biological matrices in support of PK, PD and efficacy studies.