Senior Scientist

Senior Scientist Salary Closes
CRUK-TDL, London BioScience Innovation Centre
2 year fixed term, full time position
Dependent on experience Wednesday, October 24, 2018

Shortlisting for interview will be taking place on the 1st October so early application is strongly encouraged.


CRUK Therapeutic Discovery Laboratories is the in-house CRUK drug discovery unit with a principal focus on establishing and prosecuting biologically-themed multi-project alliances with industry. Based at the London Bioscience Innovation Centre and the Babraham Research Campus, Cambridge, TDL comprises over 80 staff from both industrial and academic backgrounds.


We are looking for an innovative and ambitious Senior Scientist to join our Target Validation and Disease Positioning group to use your skills, knowledge and experience to

  • Support our expanding activities in the field of post-translational modifications
  • Take responsibility for progressing project biology and lead a small team of biologists to deliver on specific project goals and deadlines
  • Use genetic manipulation and/or gene editing techniques to address key target validation and disease positioning questions
  • Design, perform and interpret complex cell-based assays and mechanism of action studies to characterise small molecule inhibitors to inform drug discovery projects
  • Contribute to overcoming conceptual and technical challenges
  • Work collaboratively with multi-disciplinary research teams, both internally and externally


To see the full job description please click here


At TDL we bring together the best minds in basic and clinical cancer research, the rigour and drive of pharmaceutical and biotech companies, and our in-house drug discovery and alliance management capabilities to deliver breakthrough medicines for cancer patients.

In recent years, we have established successful alliances with AstraZeneca, FORMA Therapeutics, Merck KGaA, Celgene and LifeArc (formerly MRCT). We have also been successful in implementing the alliance model through the formation of spin-out companies, including Artios and iOnctura.

Our laboratories house the personnel and equipment to progress projects from initial hypothesis through to selection of candidate drugs for regulatory development. We couple this with a deep understanding of academic and industrial drivers, enabling us to build alliances that satisfy the curiosity of basic research and the rigour of drug discovery.

The successful applicant will form an integral part of the CRUK-TDL team working alongside our industry partners to progress novel cancer targets through the drug discovery process. The position would suit

  • A committed and enthusiastic PhD educated scientist with post-doctoral research experience (or equivalent) and a proven track record in oncology research
  • A researcher with knowledge of drug discovery, used to working in collaboration with, or previously employed by, a biotechnology or pharmaceutical company
  • A biologist with prior experience in the field of post-translational modification, and an ability to appraise novel targets in this space for their potential from a translational perspective
  • A strong team player with excellent communication and organisation skills
  • An expert in the use of cell culture, able to demonstrate a broad range of techniques applicable to target validation and development of cell-based assays; including the use of technologies for the modulation of target expression/activity, detection of gene / protein expression, and phenotypic evaluation


Apply now and help us bring forward the day when all cancers are cured.